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Literature summary for 2.7.8.43 extracted from

  • Harper, M.; Wright, A.; Michael, F.; Li, J.; Lucas, D.; Ford, M.; Adler, B.; Cox, A.; Boyce, J.
    Characterization of two novel lipopolysaccharide phosphoethanolamine transferases in Pasteurella multocida and their role in resistance to cathelicidin-2 (2017), Infect. Immun., 85, e00557 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Pasteurella multocida
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Pasteurella multocida X73
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Synonyms

Synonyms Comment Organism
A0R63_06305
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 Pasteurella multocida
EptA
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 Pasteurella multocida
PetL
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 Pasteurella multocida

Expression

Organism Comment Expression
Pasteurella multocida PetL expression is positively regulated by the global regulator Fis and negatively regulated by an Hfq-dependent small RNA additional information

General Information

General Information Comment Organism
physiological function phosphatidylethanolamine is transferred to lipid A by EptA homologue, PetL, and is transferred to galactose by a phosphatidylethanolamine transferase that is unique to Pasteurella multocida called PetG. The presence of a functional petL and petK, which iis responsible for PEtn addition to the single Kdo molecul, an therefore the presence of phosphatidylethanolamine on lipid A and Kdo1, i essential for resistance to the antimicrobial peptide cathelicidin-2. An enzyme inactivation mutant grows similar to wild-type Pasteurella multocida